genetics

Genetic Variants Associated with ALT Elevation from Therapeutic Acetaminophen
Several studies have suggested genetic variants associated with acetaminophen induced liver injury following overdose. It is unclear if …
Andrew A. Monte, Ian Arriaga-MacKenzie, Jack Pattee, Sasha Kaiser, Emileigh Willems, Barry Rumack, Katherine Reynolds, Richard C. Dart, Kennon J. Heard
Summix: A method for detecting and adjusting for population structure in genetic summary data
Summix is method to efficiently deconvolute ancestry and provide ancestry-adjusted allele frequencies from summary data.
Ian Arriaga-MacKenzie, Gregory Matesi, Samuel Chen, Alexandria Ronco, Katie M. Marker, Jordan R. Hall, Ryan Scherenberg, Mobin Khajeh-Sharafabadi, Yinfei Wu, Christopher R. Gignoux, Megan Null, Audrey E. Hendricks
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Summix: A method for detecting and adjusting for population structure in genetic summary data
Binomial Distribution of Allele Data
The log-likelihood can be maximized under an assumption of a binomial mixture to infer ancestry.
Ian Arriaga-MacKenzie
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Binomial Distribution of Allele Data