Genetic Variants Associated with ALT Elevation from Therapeutic Acetaminophen

Andrew A. Monte, Ian Arriaga-MacKenzie, Jack Pattee, Sasha Kaiser, Emileigh Willems, Barry Rumack, Katherine Reynolds, Richard C. Dart, Kennon J. Heard
May, 2022

Abstract

Several studies have suggested genetic variants associated with acetaminophen induced liver injury following overdose. It is unclear if genetic variants in metabolic genes or genes associated with immune mediated liver injury (DILI) are associated with acetaminophen induced alanine aminotransferase elevation during therapeutic dosing. Acetaminophen induced ALT elevation at therapeutic doses is not associated with variants in genes associated with acetaminophen metabolism.

Type
Preprint
Publication
Work In Progress
genes acetaminophen liver damage copy number variants genetics
Ian Arriaga-MacKenzie
Ian Arriaga-MacKenzie
Statistics and Computational Mathematics

My interests include optimization, algorithm design, and efficient experiment implementation.